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Related Experiment Video

Updated: Jul 5, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Default mode network as revealed with multiple methods for resting-state functional MRI analysis.

Xiang-Yu Long¹, Xi-Nian Zuo, Vesa Kiviniemi

¹State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.

Journal of Neuroscience Methods

|May 20, 2008

Summary

This summary is machine-generated.

Researchers confirmed two key brain networks, the default mode network and its anti-correlated network, during rest using fMRI. These networks are consistently active and highly integrated in the human brain.

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Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

Area of Science:

Neuroscience
Cognitive Neuroscience

Background:

Resting-state human brain activity is increasingly studied.
Two prominent networks, the default mode network and its anti-correlation network, have been identified.
Brain areas within the default mode network are crucial for mental activity.

Purpose of the Study:

To further discern the default mode network and its anti-correlation network during resting-state.
To validate findings across multiple analytical methods and independent datasets.

Main Methods:

Resting-state functional magnetic resonance imaging (fMRI) data analyzed.
Three distinct analytical methods employed: regional homogeneity, linear correlation, and independent component analysis.
Data from four independent groups of normal adults utilized.

Main Results:

The default mode network and its anti-correlation network were prominently and consistently identified across all three methods.
Consistency of these networks was observed in four independent adult datasets.
Evidence of high intra- and inter-regional integration within these anti-correlated networks was found.

Conclusions:

The study confirms the robust existence and consistency of the default mode network and its anti-correlation network during resting-state.
These findings highlight the significant integration of brain areas within these networks.
The results provide a deeper understanding of brain functional organization during rest.