Related Experiment Video

Updated: Jul 5, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Motor variant of chronic inflammatory demyelinating polyneuropathy in a child

Durriyah D Sinno1, Basil T Darras, Bassem I Yamout

  • 1Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Pediatric Neurology
|May 20, 2008
PubMed

Insights

This case study details a rare pediatric motor variant of chronic demyelinating inflammatory polyneuropathy in a 5-year-old girl. The patient showed improvement with immunotherapy, highlighting treatment responses in this uncommon condition.

Area of Science:

  • Neurology
  • Immunology
  • Pediatrics

Background:

  • Chronic demyelinating inflammatory polyneuropathy (CDIP) is rare in children.
  • Pure motor and motor variant CDIP are exceptionally uncommon pediatric presentations.

Observation:

  • A 5-year-old girl presented with 12 months of progressive motor weakness and no sensory deficits.
  • The patient was diagnosed with a motor variant of CDIP associated with anti-ganglioside antibodies.

Findings:

  • Initial partial response to intravenous immunoglobulin (IVIg) therapy.
  • Sustained, albeit incomplete, improvement with chronic prednisone treatment.

Implications:

  • This case expands the understanding of pediatric CDIP variants.
  • It suggests potential therapeutic avenues for similar rare pediatric neuropathies.
  • Highlights the importance of considering anti-ganglioside antibodies in pediatric motor neuropathies.

More Related Videos

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments07:30

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Published on: November 9, 2017

A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice04:55

A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

Published on: May 11, 2022

Related Concept Videos

Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...