Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetic Neuropathy

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Diabetic Nephropathy

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

Complications of Diabetes Mellitus

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Review of Outcomes After Peripheral Nerve Transfers for Motor Nerve Injury in the Upper Extremity.

JBJS reviews·2025

Same author

The Effect of Height on Adverse Short-Term Outcomes After Lower-Extremity Bypass Surgery in Patients with Diabetes Mellitus.

Journal of the American Podiatric Medical Association·2024

Same author

A Comparison of Adverse Short-Term Outcomes After Forefoot Amputation Based on Patient Height.

Journal of the American Podiatric Medical Association·2024

Same author

Patient-Reported Outcomes and Provocative Testing in Peripheral Nerve Injury and Recovery.

Journal of brachial plexus and peripheral nerve injury·2023

Same author

Assessment of Motor Function in Peripheral Nerve Injury and Recovery.

Orthopedic reviews·2022

Same author

Surgical Treatment Strategies for Injuries of the "Unforgiving" Superficial Branch of the Radial Nerve.

Plastic and reconstructive surgery·2022

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Published on: July 14, 2023

Painful diabetic neuropathy.

Rhonda S Cornell¹, Ivica Ducic

¹Attn: GME/Podiatic Surgery Department, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, USA. rcornell34@gmail.com <rcornell34@gmail.com>

Clinics in Podiatric Medicine and Surgery

|May 20, 2008

Summary

Diabetic neuropathy causes chronic pain, often seen by podiatric physicians. This review covers its causes, diagnosis, and treatment, including medical and surgical options for better patient outcomes.

Area of Science:

Podiatry
Neurology
Pain Management

Background:

Podiatric physicians frequently manage complex neuropathic pain.
Diabetic neuropathy is a common chronic neuropathic pain condition encountered in practice.

Purpose of the Study:

To review the pathophysiology of diabetic neuropathy.
To discuss diagnostic methods for diabetic neuropathy.
To outline current treatment options, including medical and surgical interventions.

Main Methods:

Literature review of pathophysiology, diagnosis, and treatment of diabetic neuropathy.
Discussion of clinical considerations for patient selection.
Emphasis on preventative strategies.

Main Results:

Related Experiment Videos

Last Updated: Jul 5, 2026

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Published on: July 14, 2023

Diabetic neuropathy involves complex pathophysiology contributing to chronic pain.
Accurate diagnosis is crucial for effective management.
A range of medical and surgical treatments are available.

Conclusions:

Effective management of diabetic neuropathy requires understanding its pathophysiology and diagnosis.
Careful patient selection and preventative measures are key to successful treatment.
Integrated approaches combining medical and surgical interventions can improve patient outcomes.