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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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Published on: May 22, 2018

Catalytic antibodies to amyloid beta peptide in defense against Alzheimer disease

Hiroaki Taguchi1, Stephanie Planque, Yasuhiro Nishiyama

  • 1Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, TX 77030, USA.

Autoimmunity Reviews
|May 20, 2008
PubMed

Immunoglobulins (Igs) that bind amyloid beta peptide (Abeta) are under clinical trials for immunotherapy of Alzheimer disease (AD). We have identified IgMs and recombinant Ig fragments that hydrolyze Abeta. Hydrolysis of peripheral Abeta by the IgMs may induce increased Abeta release from the brain. The catalytic IgMs are increased in AD patients, presumably reflecting a protective autoimmune response. Reduced Abeta aggregation and neurotoxicity attributable to the catalytic function were evident. These findings provide a foundation for development of catalytic Igs for AD immunotherapy.

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