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Related Experiment Video

Updated: Jul 5, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
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Published on: August 24, 2019

Lower limb activity and its determinants in COPD.

P P Walker1, A Burnett, P W Flavahan

  • 1Division of Infection and Immunity, School of Clinical Science, University of Liverpool, Liverpool, UK. ppwalker@liv.ac.uk

Thorax
|May 20, 2008
PubMed
Summary

Patients with chronic obstructive pulmonary disease (COPD) have reduced leg activity compared to healthy individuals. Pulmonary rehabilitation improves daily activity, which is linked to lung function (FEV(1)) but not walking distance.

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Area of Science:

  • Pulmonary Medicine
  • Rehabilitation Science
  • Activity Monitoring

Background:

  • Patients with chronic obstructive pulmonary disease (COPD) exhibit reduced physical activity compared to healthy older adults.
  • Self-reported activity in COPD patients is linked to exacerbation risk, but objective measures of daily and lower limb activity remain underexplored.
  • The relationship between objectively assessed daily activity and laboratory assessments before and after rehabilitation in COPD is not well understood.

Purpose of the Study:

  • To investigate the relationship between lower limb activity and total daily activity in COPD patients.
  • To compare objectively assessed daily activity in COPD patients with healthy controls.
  • To examine the impact of pulmonary rehabilitation on daily activity and its correlation with clinical outcomes.

Main Methods:

  • Lower limb activity was measured using leg actigraphy over three days in 45 moderate-to-severe COPD patients and 18 age-matched controls.
  • Thirty-three COPD patients underwent an 8-week pulmonary rehabilitation program.
  • Changes in leg activity were measured and correlated with other outcomes, including lung function (FEV(1)) and muscle strength.

Main Results:

  • Leg activity in COPD patients was closely correlated with whole-body activity but significantly reduced compared to controls.
  • Activity levels (mean leg activity, intensity, and time spent mobile) were related to forced expiratory volume in 1 second (FEV(1)).
  • Pulmonary rehabilitation led to significant improvements in mean activity and time spent mobile, correlating with baseline FEV(1) but not with improvements in muscle strength or walking distance.

Conclusions:

  • Total daily activity in COPD patients is strongly linked to leg activity, which is diminished compared to controls.
  • Objective and subjective daily activity improve post-pulmonary rehabilitation, with improvements predicted by baseline FEV(1).
  • The observed changes in activity after rehabilitation are independent of improvements in walking distance or health status.