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Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins

Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins

Published on: November 18, 2016

Primary intimal aortic angiosarcoma in a dog.

R S Ranck¹, K E Linder, M D Haber

¹Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA.

Veterinary Pathology

|May 20, 2008

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A rare aortic angiosarcoma was found in a German Shepherd, causing organ damage due to blood clots. This study details the first canine case of this aggressive vascular tumor.

Area of Science:

Veterinary Pathology
Oncology
Cardiovascular Disease

Background:

Primary aortic angiosarcoma is a rare vascular malignancy in humans.
Thromboembolic disease can arise from aortic pathologies.
German Shepherds are predisposed to various neoplastic conditions.

Observation:

A 4-year-old female German Shepherd presented with signs of widespread thromboembolism.
Gross examination revealed an aneurysmal aorta with a necrotic mass occluding the lumen.
Histopathology showed a plaque-like intimal tumor composed of neoplastic spindle cells.

Findings:

The tumor cells expressed endothelial markers (vimentin, CD31, factor VIII-related antigen) and invaded perivascular tissues.
Neoplastic cells were identified within thromboemboli associated with organ infarcts.

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Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins

Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins

Published on: November 18, 2016

Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta

Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta

Published on: February 7, 2018

Immunohistochemistry confirmed the endothelial origin of the aortic tumor.

Implications:

This is the first documented case of primary intimal aortic angiosarcoma in a dog.
The findings expand the understanding of vascular tumors in veterinary oncology.
Early diagnosis and understanding of this rare condition are crucial for canine cardiovascular health.