Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydroxyapatite cement. I. Basic chemistry and histologic properties.

P D Costantino1, C D Friedman, K Jones

  • 1Department of Otolaryngology-Head and Neck Surgery, Northwestern University Medical School, Chicago, Ill.

Archives of Otolaryngology--Head & Neck Surgery
|April 11, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concurrent chemoradiotherapy for N2 or N3 squamous cell carcinoma of the head and neck from an occult primary.

Annals of oncology : official journal of the European Society for Medical Oncology·2003
Same author

Hydroxyapatite cement, a smart biomaterial for craniofacial skeletal tissue engineering.

Surgical technology international·2003
Same author

Current use of bone substitutes in maxillofacial surgery.

Facial plastic surgery : FPS·2002
Same author

Leiomyosarcoma of the sinonasal tract: report of a case.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2001
Same author

Future directions in biomaterial implants and tissue engineering.

Archives of facial plastic surgery·2001
Same author

Sphenoethmoid cerebrospinal fluid leak repair with hydroxyapatite cement.

Archives of otolaryngology--head & neck surgery·2001
Same journal

Pathology quiz case 2.

Archives of otolaryngology--head & neck surgery·2014
Same journal

Pathology quiz case 1.

Archives of otolaryngology--head & neck surgery·2014
Same journal

Radiology quiz case 1: diagnosis.

Archives of otolaryngology--head & neck surgery·2013
Same journal

Pair of red and green macaws.

Archives of otolaryngology--head & neck surgery·2013
Same journal

Pathology quiz case 2: diagnosis.

Archives of otolaryngology--head & neck surgery·2013
Same journal

About this journal.

Archives of otolaryngology--head & neck surgery·2013
See all related articles

Hydroxyapatite cement shows potential for skeletal tissue reconstruction. This biocompatible material demonstrated resorption and bone formation in vivo, particularly on calvarial surfaces.

Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • Tissue Engineering

Background:

  • Hydroxyapatite cement (HAC) is a moldable calcium phosphate biomaterial.
  • It forms a microporous hydroxyapatite implant in vivo.
  • Its biocompatibility and bone integration potential require further investigation.

Purpose of the Study:

  • To evaluate the histologic response to hydroxyapatite cement implants.
  • To assess the influence of macroporosity on implant resorption and bone formation.
  • To determine the suitability of HAC for skeletal tissue reconstruction.

Main Methods:

  • Hydroxyapatite cement disks with varying macroporosity (0%, 10%, 20%) were implanted in cats.
  • Implants were placed in subcutaneous, intramuscular, subperiosteal, and calvarial locations.

Related Experiment Videos

  • Histologic analysis was performed up to 9 months post-implantation.

    • Main Results:

    • No toxic reactions, extrusion, or infections were observed.
    • A transient inflammatory response occurred without foreign body reaction.
    • Implant resorption correlated with macropore content, except on the calvarium.
    • Bone formation and replacement of implants occurred at the skull-implant interface.

    Conclusions:

    • Hydroxyapatite cement is biocompatible and elicits a mild inflammatory response.
    • The material can be resorbed and replaced by bone, especially on calvarial surfaces.
    • HAC shows promise for reconstructing non-stress-bearing skeletal defects.