Simulation of stress urinary incontinence for in-vitro studies

A simulation system that generates dynamic bladder pressures for the use of testing and examining artificial urinary sphincters is designed, implemented, and compared to in-vivo measurements of Valsalva and coughing profiles. Cylinder and piston, which are integrated into the universal testing machine, simulating the bladder are connected with explanted sow urethras. The AMS 800 artificial urinary sphincter closes the urethra with well-defined external pressures. In order to select appropriate profiles for the bladder pressure, 34 Valsalva and coughing profiles of 6 patients were evaluated with respect to amplitude, pressure raise, dwell time, and half width.