Related Experiment Video
Updated: Jul 5, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
Published on: May 16, 2016
Effects of inflammation on pharmacokinetics/pharmacodynamics: increasing recognition of its contribution to
1Department of Clinical Pharmacokinetics/Modeling and Simulation, GlaxoSmithKline, Research Triangle Park, North Carolina, USA. ginny.d.schmith@gsk.com
Abstract:
Inflammation is an interesting phenomenon that crosses many disciplines as part of the host response to disease, whether it is the acute response to an infectious, traumatic, or surgical event or the more chronic responses to systemic disease such as malignancy, rheumatoid arthritis, asthma, inflammatory bowel disease, or diabetes. The impact of inflammatory states on the variability in drug response should be an integral part of research conducted across disciplines within clinical pharmacology.
Related Concept Videos
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Dosage Regimen: Individualization
Pharmacogenetics of Drug Metabolism: Overview
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Drug toxicity: Idiosyncratic Reactions
Pharmacokinetics: Drug–Drug Interactions
