Related Experiment Video
Updated: Jul 5, 2026

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
[Surgical treatment of lamellar macular hole]
C Engler1, K B Schaal, A E Höh
1Schwerpunkt Retinologie, Universitäts-Augenklinik, Im Neuenheimer Feld 400, 69120 Heidelberg, Deutschland.
Purpose:
Vitrectomy and peeling in patients with lamellar macular hole was evaluated with regard to anatomical and functional outcome.
Patients And Methods:
In a retrospective study, 10 patients with lamellar macular hole underwent vitrectomy, membrane-peeling (epiretinal membrane [ERM] and internal limiting membrane [ILM]) and gas (n=9) or silicone oil (n=1) endotamponade. In most patients (n=9), cataract surgery was also performed. Pre- and postoperative ocular coherence tomography (OCT) findings, visual acuity (ETDRS), and Birkhäuser near visual acuity were evaluated.
Results:
Mean follow-up was 15+/-11 months after surgery with a minimum follow-up of 6 months. Best corrected visual acuity (BCVA) improved in all patients; the average BCVA gain was 3+/-2 lines. Preoperative mean BCVA was 0.35 (0.45+/-0.23logMAR), and postoperative BCVA was 0.64 (0.19+/-0.21logMAR). Eight of ten patients had a postoperative BCVA > or =20/40, and six patients had a postoperative BCVA > or =20/25. Mean near visual acuity was 0.5+/-0.26 (range 0.2-0.9). Postoperative OCT revealed a closed lamellar macular hole in six patients, with restored foveal contour in three of them. The other four patients showed a persistent inner retinal defect with an intact photoreceptor layer.
Conclusion:
Surgical treatment including vitrectomy, ERM-ILM-peeling and endotamponade appears to benefit patients with lamellar macular hole. All patients improved functionally. Surgical treatment can close the lamellar macular hole and restore foveal architecture.
Related Concept Videos
Angle Closure Glaucoma: Treatment
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...

