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Updated: Jul 5, 2026
10:26
Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
Published on: November 1, 2017
Tumor targeting using liposomal antineoplastic drugs.
Jörg Huwyler1, Jürgen Drewe, Stephan Krähenbuhl
1University of Applied Sciences Northwestern Switzerland, Institute of Pharma Technology, Muttenz, Switzerland. joerg.huwyler@fhnw.ch
International Journal of Nanomedicine
|May 21, 2008
Summary
Liposomes, phospholipid vesicles, are increasingly used as carriers for antineoplastic drugs. These advanced drug delivery systems improve chemotherapy effectiveness and reduce side effects for cancer treatment.
Area of Science:
- Pharmaceutical Sciences
- Biotechnology
- Oncology
Background:
- Liposomes (microparticulate phospholipid vesicles) are gaining prominence as pharmaceutical carriers.
- Their application in oncology has seen significant growth.
- They offer solutions for enhancing drug solubility and targeted delivery.
Purpose of the Study:
- To review the principles of various liposomal technologies.
- To discuss current research trends in liposomal drug delivery for cancer therapy.
Main Methods:
- Review of existing literature on liposomal formulations.
- Analysis of different liposomal technologies for drug targeting.
- Discussion of advancements in pegylated and vector-conjugated liposomes.
Main Results:
- Liposomes enhance solubility of poorly soluble antitumor drugs.
- Pegylated liposomes enable passive targeting of solid tumors.
- Vector-conjugated liposomes facilitate active targeting of tumor tissue.
- These strategies improve anticancer chemotherapy efficacy and reduce toxicity.
Conclusions:
- Liposomal drug delivery systems represent a significant advancement in cancer chemotherapy.
- Ongoing research focuses on optimizing liposomal technologies for enhanced therapeutic outcomes and reduced side effects.
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