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Updated: Jul 5, 2026

Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
Published on: November 1, 2017
Tumor targeting using liposomal antineoplastic drugs
Jörg Huwyler1, Jürgen Drewe, Stephan Krähenbuhl
1University of Applied Sciences Northwestern Switzerland, Institute of Pharma Technology, Muttenz, Switzerland. joerg.huwyler@fhnw.ch
Abstract:
During the last years, liposomes (microparticulate phospholipid vesicles) have been used with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumor drugs, the use of pegylated liposomes for passive targeting of solid tumors as well as vector-conjugated liposomal carriers for active targeting of tumor tissue. Such formulation and drug targeting strategies enhance the effectiveness of anticancer chemotherapy and reduce at the same time the risk of toxic side-effects. The present article reviews the principles of different liposomal technologies and discusses current trends in this field of research.
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