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Related Experiment Video

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Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

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Published on: April 19, 2024

[Microflora in patients with systemic connective tissue diseases].

V A Romanov, N P Shilkina, M Iu Gul'neva

Vestnik Rossiiskoi Akademii Meditsinskikh Nauk

|May 21, 2008

Summary

Systemic connective tissue diseases alter microflora, decreasing beneficial bacteria like E. coli and increasing opportunistic pathogens. This impacts skin, gut, and urinary tract microbial communities.

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Area of Science:

Microbiology
Immunology
Rheumatology

Context:

Systemic connective tissue diseases (SCTD) significantly impact multiple organ systems.
Altered microbial communities (dysbiosis) are increasingly recognized as contributing factors in various diseases.
Understanding microflora changes in SCTD is crucial for disease management.

Purpose:

To investigate the quantitative and qualitative changes in microflora across different body sites in patients with SCTD.
To compare microflora alterations in systemic lupus erythematosus (SLE) and progressive systemic sclerosis (PSS).

Summary:

Microflora analysis of skin, nose, mouth, intestinal, and urinal tracts in SCTD patients revealed a decrease in dominant beneficial bacteria.
An increase in pseudopathogenic bacteria was observed across various body sites.
Specific findings include increased Staphylococcus aureus on skin and mucous membranes, and reduced E. coli, Bifidobacterium, and Lactobacterium in the intestine.
Urinary tract microbial detection frequency decreased.
Comparative analysis of SLE and PSS patients showed common patterns of microflora alteration.

Impact:

Highlights the significant role of microbial dysbiosis in the pathogenesis of systemic connective tissue diseases.
Provides insights into potential diagnostic or therapeutic targets related to microflora modulation in SCTD.
Suggests common microbial signatures associated with different types of systemic connective tissue diseases.