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An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Synthesis and antidiabetic activity of some new thiazolyl-2,4-thiazolidinediones
Oya Bozdağ-Dündar1, Arzu Menteşe, Eugen J Verspohl
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Ankara, Turkey. bozdag@pharmacy.ankara.edu.tr
Abstract:
In this study, a series of thiazolyl-2,4-thiazolidinediones (VIa-f, VIHa-f and VIIa-f) was prepared by Knoevenagel reaction of substituted phenacyl-2,4-thiazolidinediones (IVa-f)/substituted benzyl-2,4-thiazolidinediones (Va-f) with chlorothiazolecarbaldehydes (II, III). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. A significant insulinotropic effect was seen with compounds VIa, VIb, VIe, VIIa, VIIb and VIIId. Introducing a 2-[(phenylethyl)thio] group into the thiazole ring increased the biological effect, whereas NO2 groups in phenylacyl or benzyl groups diminished the effects.
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