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Management of low-risk metastatic gestational trophoblastic tumors
B DuBeshter1, R S Berkowitz, D P Goldstein
1Department of Obstetrics and Gynecology, University of Rochester School of Medicine, Strong Memorial Hospital, NY.
The Journal of Reproductive Medicine
|January 1, 1991
Abstract:
The clinical course of 48 patients with low-risk metastatic gestational trophoblastic tumors (GTTs) treated with primary single-agent chemotherapy was reviewed. All patients achieved sustained remission, although 25 (51%) required a second single-agent regimen, and 7 (14%) needed combination chemotherapy to achieve it. An average of 3.4 courses of chemotherapy were necessary to achieve remission, and 6 patients (12%) underwent resection of resistant tumor foci. Primary single-agent chemotherapy is a reasonable treatment option in patients with low-risk metastatic GTT.