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Related Experiment Video

Updated: Jul 5, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Captopril-induced lichen planus pemphigoides.

Chaker Ben Salem¹, Lilia Chenguel, Najet Ghariani

¹Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Tunisia.

Pharmacoepidemiology and Drug Safety

|May 21, 2008

Summary

Captopril may induce lichen planus pemphigoides (LPP), a rare skin condition. This case highlights the importance of considering drug-induced LPP in patients presenting with unusual eruptions.

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Area of Science:

Dermatology
Pharmacology

Background:

Lichen planus pemphigoides (LPP) is a rare autoimmune blistering disease.
It typically presents as a mixture of lichen planus and bullous pemphigoid features.
LPP is often idiopathic but can be drug-induced.

Observation:

A 74-year-old woman developed a pruriginous and bullous lichenoid eruption.
The eruption began after initiating captopril for hypertension.
Histopathological and immunological findings confirmed LPP.

Findings:

Discontinuation of captopril and corticosteroid therapy led to resolution of LPP.
No relapse occurred eight months after stopping oral steroids.
This case suggests a potential link between captopril and LPP development.

Implications:

Clinicians should consider captopril as a potential cause of LPP.
Awareness of drug-induced LPP is crucial for accurate diagnosis and management.
This case adds to the literature on rare adverse drug reactions affecting the skin.