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Updated: Jul 5, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Internal structure of a thin film of mixed polymeric micelles on a solid/liquid interface
Ilja K Voets1, Wiebe M de Vos, Bas Hofs
1Laboratory of Physical Chemistry and Colloid Science, Wageningen University, Dreijenplein 6, Wageningen, The Netherlands. ilja.voets@wur.nl
Abstract:
The adsorption of mixed micelles of poly(4-(2-amino hydrochloride-ethylthio)-butylene)- block-poly(ethylene oxide), PAETB 49- b-PEO 212 and poly(4-(2-sodium carboxylate-ethylthio)-butylene)- block-poly(ethylene oxide), PCETB 47- b-PEO 212 on solid/liquid interfaces has been studied with light, X-ray, and neutron reflectometry. The structure of the adsorbed layer can be described with a two-layer model consisting of an inner layer formed by the coacervate of the polyelectrolyte blocks PAETB 49 and PCETB 47 ( approximately 1 nm) and an outer layer of PEO 212 blocks ( approximately 6 nm). The micelles unfold upon adsorption forming a rather homogeneous flat layer that exposes its polyethylene oxide chains into the solution, thus rendering the surface antifouling after modification with the micelles.
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