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Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...

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Related Experiment Video

Updated: Jul 5, 2026

Detection of In Situ Protein-protein Complexes at the Drosophila Larval Neuromuscular Junction Using Proximity Ligation Assay
10:31

Detection of In Situ Protein-protein Complexes at the Drosophila Larval Neuromuscular Junction Using Proximity Ligation Assay

Published on: January 20, 2015

Defining a modular signalling network from the fly interactome.

Anaïs Baudot1, Jean-Baptiste Angelelli, Alain Guénoche

  • 1Institut de Biologie du Développement de Marseille-Luminy, UMR6216, CNRS/Université de Méditerranée, Marseille, France. abaudot@cnio.es

BMC Systems Biology
|May 21, 2008
PubMed
Summary
This summary is machine-generated.

Signaling pathways form distinct modules within the protein-protein interaction network. These modules are highly connected and central, revealing the integrated nature of cellular signaling.

More Related Videos

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains
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Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains

Published on: November 6, 2017

Related Experiment Videos

Last Updated: Jul 5, 2026

Detection of In Situ Protein-protein Complexes at the Drosophila Larval Neuromuscular Junction Using Proximity Ligation Assay
10:31

Detection of In Situ Protein-protein Complexes at the Drosophila Larval Neuromuscular Junction Using Proximity Ligation Assay

Published on: January 20, 2015

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains
10:13

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains

Published on: November 6, 2017

Area of Science:

  • Systems Biology
  • Network Biology
  • Molecular Biology

Background:

  • Signaling pathways transmit information from cell surface receptors to intracellular effectors.
  • These pathways involve complex molecular interactions, including protein-protein interactions.
  • Understanding signaling mechanisms can be enhanced by analyzing the global protein-protein interaction network.

Purpose of the Study:

  • To investigate the organization of signaling pathways within the protein-protein interaction network.
  • To gain an integrated view of signaling mechanisms by studying network organization.
  • To identify novel proteins involved in signaling pathways.

Main Methods:

  • Applied graph-theory based methods to analyze the fly protein-protein interaction network.
  • Examined the topological properties of signaling pathways within the network.
  • Identified signaling modules and their connections.

Main Results:

  • Each signaling pathway is organized into two to three distinct signaling modules.
  • These modules include known signaling proteins, regulators, and predicted participants.
  • Connections between signaling modules are prominent and central within the interaction network.

Conclusions:

  • Signaling pathways form a modular sub-network within the interactome with unique topological properties.
  • This sub-network exhibits modularity, density, and centrality, reflecting integrated cell functioning.
  • Signaling plays a crucial role in connecting and coordinating biological processes at the interactome level.