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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Related Experiment Video

Updated: Jul 5, 2026

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Proteomics in atherosclerosis.

Roxana Martinez-Pinna¹, Jose Luis Martin-Ventura, Sebastian Mas

¹Vascular Research Laboratory, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040, Madrid, Spain.

Current Atherosclerosis Reports

|May 21, 2008

Summary

This summary is machine-generated.

Atherothrombosis, a major cause of death, involves vascular proteins. Proteomics offers new ways to find biological markers for cardiovascular risk.

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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

Area of Science:

Cardiovascular Research
Proteomics
Biomarker Discovery

Background:

Atherothrombosis underlies major causes of death like heart attacks and strokes.
Vascular cell and plaque proteins in plasma are modified during atherothrombosis.
These proteins are key targets for identifying novel cardiovascular risk biomarkers.

Purpose of the Study:

To review proteomic techniques for cardiovascular research.
To summarize recent findings using high-throughput proteomics on cardiovascular samples.
To highlight the potential of proteomics in discovering cardiovascular risk markers.

Main Methods:

Review of proteomic techniques.
Analysis of high-throughput proteomic data from cardiovascular samples.
Literature search for recent advancements in the field.

Main Results:

Proteomic strategies have been applied to cardiovascular samples.
Recent studies have identified potential protein biomarkers.
High-throughput proteomics shows promise for cardiovascular risk assessment.

Conclusions:

Proteomics is a valuable tool in understanding atherothrombosis.
Further research can identify novel protein biomarkers for cardiovascular risk.
Proteomic insights can advance the diagnosis and management of cardiovascular diseases.