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Genetic determinants of drug response in heart failure
Brian D Lowes1, Peter M Buttrick
1Division of Cardiology, Campus Box B130, University of Colorado Health Sciences Center, Aurora, CO 80045, USA. Brian.Lowes@UCHSC.edu
Abstract:
Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. Evidence shows that genetic factors interact with numerous heart failure medications, including vasodilators, beta blockers, and angiotensin-converting enzyme inhibitors. Technologic advances will soon allow population-based genome-wide genetic testing at a reasonable cost. Understanding the genetic factors that influence drug response in heart failure will allow physicians to personalize therapies and optimize response while minimizing serious adverse events.
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