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Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

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Collection Protocol for Human Pancreas
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Published on: May 23, 2012

Diabetes research in children network:availability of protocol data sets.

Katrina J Ruedy1, Roy W Beck, Dongyuan Xing

  • 1Jaeb Center for Health Research , Tampa, Florida.

Journal of Diabetes Science and Technology
|May 21, 2008
PubMed
Summary

The Diabetes Research in Children Network (DirecNet) evaluated type 1 diabetes technologies and factors influencing hypoglycemia. Research data and tools are publicly available to advance pediatric diabetes care.

Keywords:
continuous glucose sensorsdata setstype 1 diabetes

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Area of Science:

  • Pediatric Endocrinology
  • Biomedical Research
  • Clinical Trials

Background:

  • Established in 2001, the Diabetes Research in Children Network (DirecNet) is a collaborative network funded for type 1 diabetes research.
  • The network comprises five clinical centers, a coordinating center, and a central laboratory, facilitating multi-site research.
  • DirecNet has a strong publication record, with 28 manuscripts published and ongoing studies.

Purpose of the Study:

  • To evaluate emerging technologies for type 1 diabetes management.
  • To investigate factors influencing hypoglycemia in children with type 1 diabetes.
  • To collect and disseminate comprehensive datasets for further research.

Main Methods:

  • Evaluated various glucose monitoring devices, including home glucose meters and continuous glucose monitoring systems.
  • Assessed hemoglobin A1c (HbA1c) testing devices.
  • Conducted studies on hypoglycemia, examining factors like exercise and bedtime snack composition.

Main Results:

  • Generated extensive datasets including device performance, laboratory glucose and HbA1c levels, hormone data, and accelerometer data.
  • Developed and validated several psychosocial questionnaires relevant to type 1 diabetes management.
  • Published findings from nine completed protocols, contributing to the understanding of type 1 diabetes care.

Conclusions:

  • DirecNet has significantly contributed to the evaluation of type 1 diabetes technologies and management strategies in children.
  • The network's commitment to data sharing ensures continued research and advancement in the field.
  • Publicly accessible data and tools support ongoing efforts to improve outcomes for children with type 1 diabetes.