Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
Aromatic Hydrocarbon Anions: Structural Overview01:18

Aromatic Hydrocarbon Anions: Structural Overview

Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
Due to the absence of continuous overlap of p...
Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group with both...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Valence Bond Theory02:42

Valence Bond Theory

Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DNA-cisplatin modified single-walled carbon nanotubes for the hydrogen evolution reaction.

Nanoscale·2026
Same author

Detection of single nucleotide variants in nucleic acid biomarkers using Raman spectroscopy.

Biosensors & bioelectronics·2026
Same author

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues.

Angewandte Chemie (International ed. in English)·2025
Same author

The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A.

Nature synthesis·2025
Same author

A validated experimental NMR parameter dataset of organic molecules to assist benchmarking of 3D structure determination methods.

The Analyst·2025
Same author

IMPRESSION generation 2 - accurate, fast and generalised neural network model for predicting NMR parameters in place of DFT.

Chemical science·2025

Related Experiment Video

Updated: Jul 5, 2026

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
16:36

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels

Published on: May 18, 2009

Anion complexation via C-H...X interactions using a palladacyclic receptor.

Robin B Bedford1, Michael Betham, Craig P Butts

  • 1School of Chemistry, University of Bristol, Cantock's Close, Bristol, UKBS8 1TS. r.bedford@bristol.ac.uk

Chemical Communications (Cambridge, England)
|May 21, 2008
PubMed
Summary

A new organometallic receptor effectively binds anions in both solution and solid states. These complexes are stabilized by crucial C-HX interactions, confirmed through advanced spectroscopic and crystallographic analyses.

More Related Videos

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography
09:09

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography

Published on: September 20, 2016

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
10:01

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach

Published on: June 23, 2026

Related Experiment Videos

Last Updated: Jul 5, 2026

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
16:36

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels

Published on: May 18, 2009

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography
09:09

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography

Published on: September 20, 2016

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
10:01

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach

Published on: June 23, 2026

Area of Science:

  • Organometallic chemistry
  • Supramolecular chemistry
  • Anion recognition

Background:

  • Anion binding receptors are crucial in chemical sensing and catalysis.
  • Understanding non-covalent interactions is key to designing effective receptors.
  • Organometallic compounds offer unique electronic and structural properties for host-guest chemistry.

Purpose of the Study:

  • To develop and characterize a novel organometallic receptor for anion binding.
  • To investigate the binding modes and stability of anion complexes in different states.
  • To elucidate the role of C-HX interactions in stabilizing these complexes.

Main Methods:

  • Synthesis of a novel organometallic receptor.
  • Anion binding studies in solution using spectroscopic techniques (e.g., 1H NMR).
  • Solid-state characterization of complexes via X-ray crystallography.
  • Computational modeling to understand interaction energies and geometries.

Main Results:

  • The organometallic receptor demonstrated effective anion binding in both solution and solid states.
  • X-ray crystallography confirmed the formation of stable complexes.
  • 1H NMR spectroscopy provided evidence for anion binding and C-HX interactions.
  • Computational models corroborated the experimental findings, highlighting the role of C-HX interactions.

Conclusions:

  • A novel organometallic receptor capable of binding anions has been successfully developed.
  • The C-HX interaction is a key stabilizing force for these organometallic-anion complexes.
  • This work provides insights into the design principles for anion recognition using organometallic frameworks.