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Updated: Jul 5, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

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Published on: November 2, 2018

Dynamic protein complexes regulate NF-kappaB signaling.

E Wegener1, D Krappmann

  • 1GSF - Research Center for Environment and Health, Institute of Toxicology, Ingolstädter Landstr. 1, Neuherberg, Germany.

Handbook of Experimental Pharmacology
|May 21, 2008
PubMed
Summary

Nuclear Factor-kappaB (NF-kappaB) signaling is crucial for immune responses and stress. This review examines how large signaling complex assembly and ubiquitination regulate NF-kappaB activation, offering therapeutic targets for diseases like cancer.

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