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Atrioventricular septal defect in the fetus--associated conditions and outcome in 246 cases

C Berg1, C Kaiser, F Bender

  • 1Department of Obstetrics and Prenatal Medicine, University of Bonn, Germany. christoph.berg@ukb.uni-bonn.de

Ultraschall in Der Medizin (Stuttgart, Germany : 1980)
|May 21, 2008
PubMed

Insights

Fetal atrioventricular septal defects (AVSD) often accompany chromosomal anomalies. However, fetuses with trisomy 21 show improved cardiac anatomy and survival rates compared to those with normal karyotypes.

Area of Science:

  • Cardiology
  • Prenatal Diagnosis
  • Genetics

Background:

  • Atrioventricular septal defects (AVSD) are congenital heart conditions.
  • Prenatal detection of AVSD allows for early risk assessment and management planning.

Purpose of the Study:

  • To evaluate associated conditions and outcomes of fetuses diagnosed with AVSD.
  • To compare outcomes between fetuses with trisomy 21 and those with normal karyotypes.

Main Methods:

  • Retrospective review of 246 prenatally detected AVSD cases from 1998-2006 in Germany.
  • Analysis of associated chromosomal anomalies, syndromes, and cardiac malformations.
  • Evaluation of pregnancy outcomes, including termination, in-utero demise, and survival rates.

Main Results:

  • Chromosomal anomalies were found in 52.4% of cases; trisomy 21 was associated with balanced ventricular morphology and isolated AVSD.
  • Pregnancy termination occurred in 58.5% of cases.
  • Survival rate among live births was 64.9%; fetuses with trisomy 21 had significantly better survival and biventricular repair rates.

Conclusions:

  • Fetuses with AVSD and trisomy 21 exhibit better cardiac anatomy and survival outcomes.
  • Further research is needed to clarify outcomes for euploid fetuses with isolated or balanced AVSD.
Abstract

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