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Related Experiment Video

Updated: Jul 5, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Systemic calciphylaxis.

Manika Suryadevara¹, Scott J Schurman, Steve K Landas

¹Department of Pediatrics, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA.

Pediatric Blood & Cancer

|May 21, 2008

Summary

Systemic calciphylaxis rapidly progressed in a child with acute lymphoblastic leukemia, leading to fatal cardiorespiratory arrest. Mineral supplements, while treating deficiencies, may exacerbate systemic calcium deposition in malignancy.

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Published on: June 2, 2022

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Area of Science:

Pediatric Oncology
Nephrology
Pathology

Background:

Acute lymphoblastic leukemia (ALL) treatment can involve managing complex metabolic disturbances.
Hypercalcemia is a known complication of malignancy and can be exacerbated by treatment interventions.

Observation:

An 11-year-old male with ALL developed systemic calciphylaxis during induction therapy.
Predisposing factors included hypercalcemia, supplements for pamidronate-induced hypocalcemia and hypophosphatemia, and renal insufficiency.

Findings:

The patient experienced rapid systemic calcium deposition in vital organs, including the heart, lungs, and kidneys.
Autopsy revealed diffused alveolar damage, acute tubular necrosis, chronic pancreatitis, and hepatic steatosis.
Death occurred due to cardiorespiratory arrest on day 20 of induction treatment.

Implications:

Systemic calciphylaxis can rapidly progress in pediatric patients with hypercalcemia of malignancy.
Mineral supplements (calcium and phosphate) used to manage treatment-induced deficiencies may increase systemic mineral deposition.
Careful consideration of mineral supplementation is crucial in pediatric oncology patients with hypercalcemia and renal insufficiency to avoid iatrogenic complications.