Aspects of the in vitro bioactivity of hydraulic calcium (alumino)silicate cement
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Updated: Jul 5, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials
Published on: July 8, 2021
Nichola J Coleman1, Kunle Awosanya, John W Nicholson
1School of Science, University of Greenwich, Chatham Maritime, Kent ME44TB, United Kingdom. nj_coleman@hotmail.com
Abstract:
In response to a burgeoning interest in the prospective clinical applications of hydraulic calcium (alumino)silicate cements, the in vitro bioactivity and dissolution characteristics of a white Portland cement have been investigated. The formation of an apatite layer within 6 h of contact with simulated body fluid was attributed to the rapid dissolution of calcium hydroxide from the cement matrix and to the abundance of pre-existing Si--OH nucleation sites presented by the calcium silicate hydrate phase. A simple kinetic model has been used to describe the rate of apatite formation and an apparent pseudo-second-order rate constant for the removal of HPO4(2-) ions from solution has been calculated (k(2) = 5.8 x10(-4) g mg(-1) min(-1)). Aspects of the chemistry of hydraulic cements are also discussed with respect to their potential use in the remedial treatment of living tissue.
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