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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
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Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
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Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

[Hepatitis type A with atypical course].

M Fuoti1, M Pinotti, M C Villa

  • 1Clinica Pediatrica De Marchi, Fondazione Policlinico, Mangiagalli e Regina Elena, Università degli Studi di Milano.

La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
|May 22, 2008
PubMed
Summary
This summary is machine-generated.

Hepatitis A virus infection in children is often asymptomatic. This case highlights a prolonged, cholestatic presentation in a child, unusual for Hepatitis A.

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Area of Science:

  • Pediatric infectious diseases
  • Hepatology
  • Virology

Background:

  • Hepatitis A virus (HAV) infection typically presents asymptomatically in pediatric populations.
  • While classic and atypical symptomatic forms are recognized, prolonged cholestatic presentations are less common.

Observation:

  • A pediatric case of Hepatitis A infection is presented.
  • The child exhibited marked cholestasis, a significant indicator of liver dysfunction.
  • The clinical course was unusually prolonged, deviating from typical recovery patterns.

Findings:

  • The case demonstrates a rare, prolonged cholestatic manifestation of Hepatitis A in a child.
  • Steroid treatment was administered, and its impact on the prolonged course was observed.
  • This presentation challenges the usual understanding of HAV clinical spectrum in children.

Implications:

  • This case underscores the importance of considering atypical presentations of Hepatitis A in children, especially those with prolonged cholestasis.
  • Further research may be warranted to understand the factors contributing to prolonged and cholestatic HAV infections in pediatric patients.
  • Clinical management strategies for severe or prolonged pediatric Hepatitis A may need re-evaluation.