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Published on: January 7, 2019

[Current status of antibiotic prophylaxis in primary vesicoureteral reflux in children]

Gloria Ma Fraga Rodríguez1, Joaquín Escribano Subias, Esther Benito Acin

  • 1Unidad de Nefrología Pediátrica, Hospital de la Santa Creu i Sant Pau, Universidad Autónoma de Barcelona, Barcelona, España. gfraga@santpau.es

Archivos Espanoles De Urologia
|May 22, 2008
PubMed

Insights

Antibiotic prophylaxis does not show proven benefits in preventing urinary infections or kidney damage in children with primary vesicoureteral reflux (VUR) grades I to III. More research is needed to establish clear recommendations for VUR management.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Clinical Trials Methodology

Context:

  • Primary vesicoureteral reflux (VUR) is a condition in children that can lead to urinary tract infections and renal damage.
  • The use of antibiotic prophylaxis is a common strategy to prevent these complications.

Purpose:

  • To evaluate the effectiveness of antibiotic prophylaxis in preventing urinary infections and renal parenchymal damage in pediatric patients with primary VUR.

Summary:

  • A systematic review of clinical trials and meta-analyses was conducted. While some studies suggested a reduced risk of urinary infection with antibiotics, the overall quality of evidence was insufficient.
  • Two randomized controlled trials in children with VUR grades I-III found no significant difference in urinary infection or renal damage rates between those receiving prophylaxis and those not.

Impact:

  • Current evidence does not support the routine use of antibiotics for preventing urinary infections in children with VUR grades I-III.
  • Further high-quality trials are necessary to determine appropriate prophylactic strategies for children with VUR, especially for high-grade reflux.
Abstract

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