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Updated: Jul 5, 2026

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
[Adjunct use of NovoSeven (recombinant factor VIIa) for penetrating cardiac trauma]
Luis Manuel García-Núñez1, Luis Enrique Soto-Ortega, Ruy Cabello-Pasini
1Subsección de Cirugía del Trauma, Departamento de Cirugía, Hospital Central Militar, Secretaría de la Defensa Nacional, México, D.F., Mexico. lmgarcian@hotmail.com
Background:
Uncontrolled bleeding leads to 40-86% of preventable deaths due to trauma. Use of NovoSeven (rFVIIa) in trauma is promising, although data supporting its utilization are limited.
Case Report:
We report the case of a patient who sustained a penetrating grade V cardiac injury (AAST-OIS) and presented postoperative massive coagulopathic bleeding arrested by the administration of platelet pools and NovoSeven.
Discussion:
This report represents our initial experience and the very first case of successful use of NovoSeven for the treatment of traumatic coagulopathic hemorrhage at the Central Military Hospital in Mexico City. A further prospective trial justifying its use in our institution is warranted.
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