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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: Jul 5, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

[Human embryonic stem cells: clinical potential and current challenges].

Roberto S Oliveri¹, Claus Yding Andersen

¹Rigshospitalet, Reproduktionsbiologisk Laboratorium 5712, Juliane Marie Centret, DK-2100 København Ø. oliveri@rh.dk

Ugeskrift for Laeger

|May 22, 2008

Summary

This summary is machine-generated.

Human embryonic stem cells (hESCs) hold promise for treating degenerative diseases due to their pluripotency. Clinical application requires addressing safety and immunogenicity concerns for regenerative medicine advancements.

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Derivation and Characterization of a Transgene-free Human Induced Pluripotent Stem Cell Line and Conversion into Defined Clinical-grade Conditions

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Derivation and Characterization of a Transgene-free Human Induced Pluripotent Stem Cell Line and Conversion into Defined Clinical-grade Conditions

Derivation and Characterization of a Transgene-free Human Induced Pluripotent Stem Cell Line and Conversion into Defined Clinical-grade Conditions

Published on: November 26, 2014

Area of Science:

Stem cell biology
Regenerative medicine
Developmental biology

Context:

Human embryonic stem cells (hESCs) exhibit pluripotency, enabling differentiation into diverse adult human cell types.
Potential applications include generating insulin-producing beta-cells, cardiomyocytes, and neurons for therapeutic purposes.
Current limitations involve extensive safety evaluations and overcoming immunogenic challenges for clinical translation.

Purpose:

To summarize the potential of human embryonic stem cells (hESCs) in regenerative medicine.
To highlight the key characteristics of hESCs, including their pluripotency and differentiation capacity.
To identify the primary obstacles hindering the clinical implementation of hESC-based therapies.

Summary:

hESCs are pluripotent cells capable of differentiating into various specialized cell types.
Their potential is significant for treating cellular degenerative disorders.
Clinical use necessitates rigorous safety assessments and solutions for immune rejection.

Impact:

Regenerative medicine utilizing hESCs could offer novel treatments for currently intractable diseases.
Advancements in hESC research pave the way for innovative therapeutic strategies.
Overcoming safety and immunogenicity hurdles is crucial for realizing the full potential of hESC therapies.