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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...

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Related Experiment Video

Updated: Jul 5, 2026

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
06:01

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Post-infectious functional gastrointestinal disorders in children.

Miguel Saps1, Licia Pensabene, Lucio Di Martino

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Memorial Hospital, Chicago, IL 60614, USA. msaps@childrensmemorial.org

The Journal of Pediatrics
|May 22, 2008
PubMed
Summary

Children who experience acute bacterial gastroenteritis (AGE) have a significantly higher risk of developing functional gastrointestinal disorders (FGIDs). This study highlights the long-term gastrointestinal health impact of bacterial infections in pediatric patients.

Related Experiment Videos

Last Updated: Jul 5, 2026

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
06:01

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Functional Gastrointestinal Disorders

Background:

  • Acute bacterial gastroenteritis (AGE) is a common childhood illness.
  • The long-term consequences of AGE on gastrointestinal health are not fully understood.
  • Functional gastrointestinal disorders (FGIDs) are prevalent in children and can significantly impact quality of life.

Purpose of the Study:

  • To investigate the incidence and development of FGIDs following an episode of AGE in children.
  • To compare FGID development in children with AGE versus healthy controls.

Main Methods:

  • A cohort study involving 88 children aged 3-19 years diagnosed with AGE.
  • Patients were recruited from two pediatric hospitals in the US and Italy between 2001-2005.
  • Validated FGID questionnaires assessed symptoms like abdominal pain, diarrhea, and disability at least 6 months post-infection, comparing exposed children with matched trauma/well-child controls.

Main Results:

  • 36% of children with AGE reported new-onset abdominal pain compared to 11% in controls (P < .01).
  • Irritable bowel syndrome (87%) and dyspepsia (24%) were common FGIDs diagnosed post-AGE.
  • 56% of affected children reported symptom onset directly following the bacterial infection.

Conclusions:

  • Bacterial gastroenteritis significantly increases the risk of developing functional gastrointestinal disorders in children.
  • Early identification and management of FGIDs post-infection are crucial for pediatric health.