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The superposition principle is a fundamental concept stating that in a linear circuit, the voltage across (or current through) an element can be determined by summing the individual contributions of each independent source acting in isolation. When dealing with linear circuits containing multiple independent sources, this principle serves as a valuable tool for analysis. To apply the superposition principle effectively, one should focus on a single independent source at a time while...

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Related Experiment Video

Updated: Jul 5, 2026

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

Superimpose: a 3D structural superposition server.

Raphael A Bauer¹, Philip E Bourne, Arno Formella

¹Charité-Universitätsmedizin Berlin, Structural Bioinformatics Group, Arnimallee 22, 14195 Berlin, Germany.

Nucleic Acids Research

|May 22, 2008

Summary

This summary is machine-generated.

Superimposé is a webserver for 3D structural similarity searches, aiding in drug discovery and protein functional analysis. It helps identify similar molecules, protein binding sites, and protein folds for various bioinformatics applications.

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Area of Science:

Bioinformatics
Structural Biology
Computational Chemistry

Background:

Structural similarity is crucial for understanding molecular function and interactions.
Identifying similar structures aids in drug discovery and protein analysis.

Purpose of the Study:

To introduce the Superimposé webserver for 3D structural similarity searches.
To provide a tool for comparing small molecules, protein binding sites, and entire proteins.

Main Methods:

Implementation of multiple algorithms for structural comparison.
Utilization of various databases for search queries.
User assistance in selecting optimal algorithm-database combinations.
Visual assessment of search results.

Main Results:

Detection of scaffold-hoppers among drug-like compounds.
Identification of structurally similar binding sites for functional analysis.
Discovery of proteins with similar folds but different backbone topologies.

Conclusions:

Superimposé offers a versatile platform for diverse structural similarity searches.
The webserver facilitates in silico screening for drug discovery and protein research.
Visual results enhance the interpretation of structural comparisons.