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Peripheral nervous system and spinal cord involvement in lymphoma
J Correale1, D A Monteverde, J A Bueri
1Division of Neurology, José María Ramos Mejía, Hospital, Buenos Aires, Argentina.
Acta Neurologica Scandinavica
|January 1, 1991
Summary
This study investigated neurological complications in lymphoma patients, finding spinal cord compression and Herpes zoster infections were most common. Chemotherapy-induced toxic polyneuropathy also occurred, with discontinuation potentially limiting symptom onset.
Area of Science:
- Neurology
- Oncology
- Infectious Diseases
Background:
- Lymphoma patients face various neurological complications.
- Understanding these complications is crucial for patient management and prognosis.
Purpose of the Study:
- To investigate the spectrum and frequency of neurological complications in a cohort of lymphoma patients.
- To identify predisposing factors and clinical characteristics of these complications.
Main Methods:
- Retrospective analysis of 989 lymphoma patients.
- Review of medical records for neurological diagnoses, including spinal cord compression, infections, and chemotherapy-induced polyneuropathy.
- Electrophysiological studies for neuropathy assessment.
Main Results:
- Spinal cord/root compression (4.6%) and Herpes zoster infections (4.2%) were the most frequent complications.
- Chemotherapy-induced toxic polyneuropathy affected 3.9% of patients, characterized by axonal damage.
- Advanced lymphoma stage, chemotherapy, and splenectomy were linked to infection risk.
Conclusions:
- Neurological complications are significant in lymphoma care.
- Prompt recognition and management of these issues, including potential chemotherapy adjustments, are vital.