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Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under
M Bashir-Uddin Surfraz1, Stefano C G Biagini, Philip J Blower
1Cancer Research Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.
Dalton Transactions (Cambridge, England : 2003)
|May 22, 2008
Abstract:
The trifluoroacetyl group protects the nucleophilic HYNIC from unwanted side reactions yet allows radiolabelling with technetium-99m under mild conditions, due to efficient and specific promotion of deprotection by a technetium complex intermediate.
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