Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Packaging00:58

DNA Packaging

Overview
DNA Packaging00:58

DNA Packaging

Overview
Chromatin Packaging01:32

Chromatin Packaging

Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
Chromatin Packaging02:21

Chromatin Packaging

Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.
Chromatin Packaging02:21

Chromatin Packaging

Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Fiscal Consequences for the Canadian Government of Efgartigimod in the Treatment of Generalized Myasthenia Gravis.

Journal of health economics and outcomes research·2026
Same author

Machine Learning-Based Prediction of Antimicrobial Susceptibility: A Step Towards Precision Antimicrobial Stewardship.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same author

A Multi-Phase Analysis of Blood Culture Stewardship: Machine Learning Prediction, Expert Recommendation Assessment, and LLM Automation.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same author

Impact of common artefacts on mass visibility in contrast-enhanced mammography: A virtual imaging trial.

Medical physics·2026
Same author

First, do NOHARM: towards clinically safe large language models.

ArXiv·2026
Same author

In-depth look at the use of pixel variance and the noise power spectrum in digital mammography quality control.

Journal of medical imaging (Bellingham, Wash.)·2025
Same journal

Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS.

Molecular bioSystems·2017
Same journal

Correction: Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity - a computational study.

Molecular bioSystems·2017
Same journal

Conformational heterogeneity in tails of DNA-binding proteins is augmented by proline containing repeats.

Molecular bioSystems·2017
Same journal

Mechanism of the formation of the RecA-ssDNA nucleoprotein filament structure: a coarse-grained approach.

Molecular bioSystems·2017
Same journal

Staphylococcus aureus extracellular vesicles (EVs): surface-binding antagonists of biofilm formation.

Molecular bioSystems·2017
Same journal

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases.

Molecular bioSystems·2017
See all related articles

Related Experiment Video

Updated: Jul 5, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

DNA packaging via combinative self-assembly.

Jennifer Haley1, Xiaolin Li, Nicholas Marshall

  • 1Department of Chemistry, University of Georgia, Athens, Georgia, USA.

Molecular Biosystems
|May 22, 2008
PubMed
Summary
This summary is machine-generated.

Researchers developed a new DNA packaging method using DNA-binding oligopeptides on a polymer scaffold. This approach enables the self-assembly of DNA into compact nanostructures for versatile applications.

More Related Videos

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

Related Experiment Videos

Last Updated: Jul 5, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

Area of Science:

  • Biotechnology
  • Materials Science
  • Nanotechnology

Background:

  • Efficient DNA packaging is crucial for various biotechnological applications, including gene delivery and nanotechnology.
  • Existing methods face challenges in versatility and achieving highly compact structures.

Purpose of the Study:

  • To develop a novel and versatile approach for DNA packaging.
  • To create compact DNA nanostructures through combinational self-assembly.

Main Methods:

  • Grafting DNA-binding oligopeptides onto a polymer scaffold.
  • Utilizing the self-assembly properties of the modified polymer with DNA.

Main Results:

  • Successfully created a novel DNA packaging system.
  • Demonstrated the ability to form compact nanostructures through combinational self-assembly.
  • The developed approach is versatile and adaptable for various DNA packaging needs.

Conclusions:

  • The novel DNA packaging approach using oligopeptide-functionalized polymers is effective.
  • This method offers a versatile platform for creating compact DNA nanostructures.
  • Potential applications in gene therapy, diagnostics, and nanomaterials.