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Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
Published on: January 31, 2020
Improved rheumatoid digital vasculitis in a patient treated with TNFalpha agent blocking (infliximab)
Maurizio Benucci1, Francesca Li Gobbi, Gianantonio Saviola
1Rheumatology Unit, Nuovo Ospedale S. Giovanni di Dio, ASL 10 Florence via di Torregalli 3, Florence, Italy. maubenucci@tiscali.it
Abstract:
Rheumatoid vasculitis (RV) is an uncommon but potentially catastrophic complication of rheumatoid arthritis (RA). There are few current extensive studies and no consensus regarding the clinical, laboratory, histologic features and management or prognosis of RV. We report a case of RV in a 74-year old woman with a long (14 years) history of RA, who developed vasculitis of distal arteries with gangrene of digits of upper and lower extremities. After the failure of various immunosuppressive drugs (cyclophosphamide, methotrexate), the patient was treated with anti-TNFalpha infliximab. Digital gangrene healed within four months from the start of anti-TNFalpha treatment.
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