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Genetic regulation of prefrontal cortex development and function.

Jeremy A Cholfin¹, John L R Rubenstein

¹Medical Scientist Training Program, University of California, San Francisco, CA 94143-2611, USA.

Novartis Foundation Symposium

|May 23, 2008

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Fibroblast growth factor (FGF) signaling is crucial for patterning the mammalian prefrontal cortex (PFC). FGFs, like Fgf17, regulate gene expression in the developing brain, specifying PFC regional subdivisions.

Area of Science:

Developmental Neurobiology
Genetics
Molecular Biology

Background:

The prefrontal cortex (PFC) governs higher-order behaviors, but its developmental genetic mechanisms remain poorly understood.
Fibroblast growth factor (FGF) signaling is implicated in rostral telencephalic development.

Purpose of the Study:

To investigate the role of FGF signaling in patterning the developing mammalian prefrontal cortex.
To elucidate how FGFs regulate gene expression for PFC regional specification.

Main Methods:

Analysis of FGF gene expression in the embryonic telencephalon.
Investigating the effects of FGFs on regulatory gene expression in the cortical neuroepithelium.

Main Results:

Related Experiment Videos

Specific FGF genes are expressed in the rostral patterning center.

FGF signaling, including Fgf17, modulates graded gene expression within the cortical neuroepithelium.

Conclusions:

FGF signaling plays a key role in the initial distribution and specification of prefrontal cortex regional subdivisions.
This mechanism is essential for the development of mature PFC areas.