[The role of melatonin in pathogenesis of diseases of digestive system]

The problem of duodenal ulcer (DU) in one of the most important issues in gastroenterology. Successful eradication of Helicobacter pylori leads to a significant decrease in the frequency of DU recurrence. However, in spite of modern achievement, this disease cannot be cured completely. Taking into account melatonin properties as well as the results of numerous experiments demonstrating its ulcer-protecting effects in different ulcer models, the role of disorder in the melatonin production in the occurrence and exacerbation of DU is undoubted. There are data on the participation of melatonin in the development and clinical course of such intestinal disease as various forms of colitis, irritated bowel syndrome, and "nighttime colicss". Melatonin protects pancreatic beta-cells, increases blood sugar and insulin levels, and favors depositing of glycogen and glucose uptake. A direct association between melatonin and carcinogenesis in the alimentary tract has been demonstrated experimentally.