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[Q-T interval dispersion in patients with coronary heart disease in various terms after angioplastic

A V Kuzubova, Iu I Afanas'ev, S Iu Grigorova

    Klinicheskaia Meditsina
    |May 23, 2008
    PubMed

    Insights

    Coronary atherosclerosis increases risks of sudden cardiac death due to ventricular arrhythmias. Myocardial revascularization effectively reduces these risks, with sustained benefits observed six months post-intervention.

    Area of Science:

    • Cardiology
    • Electrophysiology
    • Medical Research

    Background:

    • Ventricular rhythm disturbances are the primary cause of sudden cardiac death in 75-80% of coronary heart disease (CHD) cases.
    • The degree of coronary artery lesion significantly influences the development of these life-threatening arrhythmias.
    • QT interval dispersion is a promising noninvasive method for assessing the risk of dangerous ventricular arrhythmias.

    Purpose of the Study:

    • To investigate QT interval dispersion and its components in patients with coronary atherosclerosis.
    • To evaluate the impact of angioplasty-based myocardial revascularization on electrical instability markers.
    • To assess changes in QT interval dispersion up to six months after intracoronary intervention.

    Main Methods:

    • Analysis of QT interval dispersion and its parts in patients with coronary atherosclerosis.
    • Assessment of QT interval dispersion before and after myocardial revascularization procedures.
    • Monitoring of QT interval dispersion changes over a six-month period post-intervention, including assessment of restenosis.

    Main Results:

    • Coronary atherosclerosis significantly increases myocardial depolarization and repolarization non-homogeneity.
    • QT interval dispersion values were not correlated with the number of affected coronary arteries.
    • Myocardial revascularization led to a significant reduction in QT interval dispersion.
    • A more pronounced decrease in dispersion was observed six months after transcutaneous intracoronary intervention.
    • The development of restenosis was associated with an increase in QT interval dispersion indices.

    Conclusions:

    • Coronary atherosclerosis exacerbates myocardial electrical instability, increasing arrhythmia risk.
    • Myocardial revascularization is effective in reducing electrical instability markers.
    • QT interval dispersion serves as a reliable indicator of myocardial electrical stability and restenosis development.

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