Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

Post-traumatic Stress Disorder

Post-traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events, are a...

Increased Intracranial Pressure ll: Pathophysiology

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...

Increased Intracranial Pressure l: Introduction

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Cerebral Edema ll: Pathophysiology

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Can vagus nerve stimulation help migraine?

Cephalalgia : an international journal of headache·2008

Same author

Medication overuse headache.

Minerva medica·2007

Same author

Transient tumor attacks.

Neurology·2000

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Post-traumatic headache: from classification challenges to biological underpinnings.

¹Headache Section, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA. marc-lenaerts@ouhsc.edu

Cephalalgia : an International Journal of Headache

|June 14, 2008

Summary

Post-traumatic headache (PTH) has acute and chronic forms, with the latter potentially neuropathic. Understanding frontal lobe dysfunction in chronic PTH is key for improving patient management and therapeutic outcomes.

More Related Videos

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Related Experiment Videos

Last Updated: Jul 5, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Area of Science:

Neurology
Neuroscience
Headache Medicine

Background:

Post-traumatic headache (PTH) is classified under the International Classification of Headache Disorders, 2nd edition (ICHD-II).
PTH presents as acute or chronic, with distinct potential pathophysiological mechanisms (nociceptive vs. neuropathic).
The transition between acute and chronic PTH requires clearer biological markers.

Purpose of the Study:

To explore the clinical characteristics and potential pathogenesis of chronic post-traumatic headache.
To investigate the role of frontal lobe dysfunction in traumatic brain injury (TBI) patients experiencing PTH.
To highlight the impact of recognizing frontal lobe involvement on patient management and treatment.

Main Methods:

Review of existing literature and diagnostic criteria (ICHD-II) for post-traumatic headache.
Analysis of the potential biological underpinnings of acute versus chronic PTH.
Examination of the clinical consequences of frontal lobe injury in the context of headache.

Main Results:

Chronic PTH often mimics primary headache disorders like migraine or tension-type headache.
Frontal lobe dysfunction following head trauma can significantly influence headache symptomatology.
The biological basis of chronic PTH and its relationship to primary headaches remains poorly understood.

Conclusions:

Improved understanding of chronic PTH pathogenesis, particularly its potential neuropathic nature, is needed.
Recognizing and addressing frontal lobe dysfunction in TBI patients is crucial for optimizing PTH management.
Further research focusing on biological data is essential to refine PTH classification and treatment strategies.