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Related Experiment Videos

CD30 expression in follicular lymphoma.

M Piris1, K C Gatter, D Y Mason

  • 1Nuffield Department of Pathology, John Radcliffe Hospital, Oxford, UK.

Histopathology
|January 1, 1991
PubMed
Summary

CD30 positive cells were identified in most centroblastic/centrocytic follicular lymphomas, primarily at the edge of neoplastic follicles. These CD30 positive cells are likely B-cells and important for differential diagnosis.

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Area of Science:

  • Immunology
  • Pathology
  • Oncology

Background:

  • The CD30 antigen is a key marker for Hodgkin lymphoma and some non-Hodgkin's lymphomas.
  • CD30 expression in centroblastic/centrocytic (cb/cc) follicular lymphoma is not fully characterized.

Purpose of the Study:

  • To investigate the presence, distribution, and nature of CD30 positive cells in cb/cc follicular lymphoma.
  • To assess the diagnostic relevance of CD30 expression in this lymphoma subtype.

Main Methods:

  • Immunohistochemistry using the monoclonal antibody BerH2 to detect CD30.
  • Double immunostaining to evaluate co-expression with B-cell markers.

Main Results:

  • CD30 positive cells were found in 17 out of 19 (89.5%) cb/cc follicular lymphoma cases.
  • These cells were predominantly located at the edge of neoplastic follicles, with some in perinodular or T-cell areas.
  • Double immunostaining indicated that most CD30 positive cells were B-cells.

Conclusions:

  • CD30 positive cells are common in cb/cc follicular lymphoma and exhibit a distribution similar to reactive lymph nodes.
  • The majority of these cells appear to be B-cells, suggesting a potential role in the lymphoma's pathogenesis.
  • Identifying CD30 positive cells aids in the differential diagnosis of cb/cc lymphoma, particularly distinguishing it from Hodgkin's disease with lymphocyte predominance.

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