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Spatial encoding in spinal sensorimotor circuits differs in different wild type mice strains.

Jonas Thelin1, Jens Schouenborg

  • 1Neuronano Research Center, Department of Experimental Medical Science, Lund University, BMC F10, S-221 84, Sweden. jonas.thelin@med.lu.se

BMC Neuroscience
|May 23, 2008
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Summary

Mice and rats share similar nociceptive withdrawal reflex (NWR) spatial encoding, but impaired learning in mice affects NWR adaptation. Long-term potentiation (LTP) may influence somatosensory imprinting.

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Area of Science:

  • Neuroscience
  • Somatosensory system research
  • Animal models in pain research

Background:

  • The nociceptive withdrawal reflex (NWR) system's spatial organization adapts via experience-dependent mechanisms (somatosensory imprinting) during development in rats.
  • Previous research indicates functional adaptation in the rat NWR system, but its presence and mechanisms in mice remain less understood.

Purpose of the Study:

  • To determine if mice exhibit similar spatial encoding of sensory input to the NWR as observed in rats.
  • To investigate if mouse strains with impaired learning and long-term potentiation (LTP) show deficits in NWR adaptation.
  • To compare NWR organization in mice with normal and deficient LTP to rat models.

Main Methods:

  • Mapping receptive fields of NWR in single hindlimb muscles using CO2 laser heat pulses.
  • Utilizing two adult wild-type mouse strains with normal hippocampal LTP and two strains with deficient LTP.
  • Comparing findings in mice with previously established rat NWR data.

Main Results:

  • Mice with normal LTP demonstrated spatial organization of nociceptive receptive fields highly similar to rats.
  • Mice strains with impaired LTP exhibited aberrant sensitivity distributions in NWR receptive fields.
  • No significant differences in NWR thresholds or C-fibre latencies were observed, suggesting distinct mechanisms for reflex sensitivity and somatosensory imprinting.

Conclusions:

  • Sensory encoding in mouse and rat NWR systems is comparable when studying strains with proficient learning capabilities.
  • The findings suggest a potential involvement of LTP-like mechanisms in the process of somatosensory imprinting.
  • This study highlights the importance of learning capacity when comparing NWR adaptations across species.