[Analysis of prognostic factors in high risk gestational trophoblastic disease with respect to remission and...

Sixty-nine patients with high risk gestational trophoblastic disease (excluding invasive mole) were treated at Chiba University from 1973 to 1988. The clinical features and results of treatment which influenced remission and recurrence in these high risk patients were analyzed statistically. The factors analyzed were (1) the height of pretreatment urinary hCG titer, (2) the type of antecedent pregnancy, (3) the time interval from pregnancy to treatment, (4) the metastatic site, (5) age, (6) the type of chemotherapy, (7) the time of operation and (8) the number of additional chemotherapy courses. With respect to the remission rate and the metastatic site, the type of chemotherapy was statistically significant. In addition, the factors related to the time of operation were significant in relation to recurrence.