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Sickle red cell adhesion: many issues and some answers

D K Kaul1

  • 1Department of medicine, Ullmann 917, Albert Einstein College of Medicine, 1300 Morris Park avenue, Bronx, NY 10461, USA. kaul@aecom.yu.edu

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|May 23, 2008
PubMed

Among multiple pathologies associated with sickle cell disease, sickle red cell-endothelial interaction has been implicated as a potential initiating mechanism in vaso-occlusive events that characterize this disease. Vast literature exists on various aspects of sickle red cell adhesion, but many issues remain unresolved, especially pertaining to the role of sickle red cell heterogeneity, the relative role of multiple adhesion mechanisms and targets of antiadhesive therapy. This review briefly analyzes these issues.

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