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A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
[Changes of insulin-like growth factor-I in focal cerebral ischemical reperfusion injury in rats]
Hong-ying Wu1, Jiang-zhong Fan, Ren Luo
1Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. wuhymail@126.com
Objective:
To study the changes of insulin-like growth factor-I (IGF-I) in focal cerebral ischemical reperfusion injury model.
Methods:
Focal cerebral ischemia was induced in rats using filament method, and the expressions of IGF-I was detected with immunohistochemical staining.
Results:
The expression of IGF-I was very low in normal brain tissues, but increased in the infracted area and penumbra after cerebral ischemia. The expressions of IGF-I reached the peak level of 14.83-/+0.48 at days 3 after reperfusion.
Conclusion:
Focal cerebral ischemia reperfusion injury enhances the expression of endogenous IGF-I.
