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Complement deficiency and disease.

D J Unsworth1

  • 1Department of Immunology and Immunogenetics, Southmead Hospital, Bristol BS10 5ND, UK. joe.unsworth@nbt.nhs.uk

Journal of Clinical Pathology
|May 23, 2008
PubMed
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This review examines diseases caused by deficiencies or dysfunctions in the complement system, a crucial part of the immune response. Understanding complement dysfunction is vital for diagnosing and treating various inflammatory and autoimmune conditions.

Area of Science:

  • Immunology
  • Biochemistry

Background:

  • The complement system comprises approximately 30 serum proteins, crucial for immune responses.
  • Many complement proteins are synthesized in the liver; deficiencies are noted in liver failure.
  • Complement activation is pro-inflammatory and linked to acute phase responses and chronic inflammation.

Purpose of the Study:

  • To review disease states resulting directly from complement deficiency or dysfunction.
  • To highlight the importance of regulatory proteins in controlling complement activation.

Main Methods:

  • Literature review of complement system function and related diseases.
  • Analysis of the role of complement proteins in inflammation and immune response.

Main Results:

Related Experiment Videos

  • Complement deficiency or dysfunction can lead to various pathological conditions.
  • Dysregulation of complement activation contributes to inflammatory diseases like rheumatoid arthritis.

Conclusions:

  • The complement system plays a critical role in maintaining immune homeostasis.
  • Deficiencies and dysfunctions in the complement system are directly implicated in disease pathogenesis.