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Published on: February 28, 2012
Initial experience with bioactive cerecyte detachable coils: impact on reducing recurrence rates
Erol Veznedaroglu1, Christopher J Koebbe, Adnan Siddiqui
1Thomas Jefferson University, Department of Neurological Surgery, Philadelphia, Pennsylvania, USA. veznedaroglu@yahoo.com
Neurosurgery
|May 23, 2008
Summary
The Cerecyte bioactive coil shows promise for treating brain aneurysms, demonstrating safety and effectiveness with low retreatment rates. Further studies are needed for long-term comparisons.
Area of Science:
- Neurosurgery
- Interventional Radiology
- Biomaterials Science
Background:
- Endovascular coil embolization is a standard treatment for intracranial aneurysms.
- Concerns persist regarding the durability and retreatment rates associated with current embolic coils.
- The Cerecyte bioactive coil offers a novel approach with a bioactive polymer coating.
Purpose of the Study:
- To prospectively evaluate the safety and durability of the Cerecyte bioactive coil.
- To assess the impact of the Cerecyte coil on recanalization rates in intracranial aneurysms.
- To analyze clinical and angiographic outcomes following embolization with Cerecyte coils.
Main Methods:
- Prospective enrollment of 176 patients with 212 aneurysms over 12 months.
- Exclusion of patients receiving stent assistance or non-Cerecyte coils.
- Clinical outcome documentation and angiographic assessment at immediate post-embolization and follow-up (mean 11.2 months).
Main Results:
- Eighty-nine aneurysms in 81 patients met inclusion criteria for analysis.
- A recurrence requiring retreatment occurred in 6.7% of aneurysms due to dome filling.
- Low rates of coil compaction (4%) and one thromboembolic event (1.1%) were observed; no meningitis or hydrocephalus.
Conclusions:
- The Cerecyte bioactive coil is safe and effective for both ruptured and unruptured intracranial aneurysms.
- The coil's bioactive polymer provides handling characteristics comparable to platinum coils.
- Further long-term comparative studies against platinum and other bioactive coils are recommended.
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