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Abnormal lipid profile and hyperinsulinaemia after a mixed meal: additional cardiovascular risk factors in young

J Rotteveel1, M M van Weissenbruch, J W R Twisk

  • 1Department of Pediatrics, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands. J.Rotteveel@Vumc.nl

Diabetologia
|May 23, 2008
PubMed

Insights

Preterm birth, particularly when small for gestational age, is linked to increased postprandial triacylglycerol levels and hyperinsulinaemia in adulthood, indicating higher cardiovascular risk.

Area of Science:

  • Metabolic health
  • Cardiovascular risk factors
  • Neonatal research

Background:

  • Low birthweight, whether term or preterm, is associated with adult metabolic syndrome.
  • Individuals born preterm often have low birthweight and may develop metabolic syndrome.
  • While high blood pressure, glucose intolerance, and insulin resistance are known in preterm infants, dyslipidemia has not been previously reported.

Purpose of the Study:

  • To investigate dyslipidemia in young adults born preterm.
  • To assess cardiovascular risk factors in preterm infants using a mixed meal test.
  • To explore the relationship between preterm birth, metabolic syndrome components, and insulin sensitivity.

Main Methods:

  • Study included three groups: preterm appropriate for gestational age (POPS-AGA), preterm small for gestational age (POPS-SGA), and term normal birthweight controls (CON).
  • Fasting lipids and postprandial responses to a mixed meal test were analyzed.
  • Insulin sensitivity was measured using a hyperinsulinemic clamp.

Main Results:

  • Preterm participants exhibited higher blood pressure compared to controls.
  • Postprandial triacylglycerol levels were elevated in men born preterm small for gestational age (POPS-SGA).
  • Individuals born POPS-SGA experienced hyperinsulinemia during the mixed meal test.

Conclusions:

  • The mixed meal test is valuable for identifying cardiovascular risk factors.
  • Elevated postprandial triacylglycerol levels in POPS-SGA men suggest dyslipidemia.
  • Postprandial hyperinsulinemia in POPS-SGA individuals indicates impaired metabolic regulation.
Abstract

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