Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Published on: November 3, 2017

Enhanced rat sciatic nerve regeneration through silicon tubes implanted with valproic acid.

Fei Wu¹, Danmou Xing, Zhengren Peng

¹Department of Hand Surgery and Microsurgery, Pu Ai Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan City, Hu Bei Province, People's Republic of China.

Journal of Reconstructive Microsurgery

|May 23, 2008

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Retracted] MicroRNA‑643 regulates the expression of ZEB1 and inhibits tumorigenesis in osteosarcoma.

Molecular medicine reports·2022

Same author

Integrated Bioinformatics-Based Identification of Potential Diagnostic Biomarkers Associated with Diabetic Foot Ulcer Development.

Journal of diabetes research·2021

Same author

Functional Analysis of Estrogen Receptor 1 in Diabetic Wound Healing: A Knockdown Cell-Based and Bioinformatic Study.

Medical science monitor : international medical journal of experimental and clinical research·2020

Same author

Arbuscular mycorrhizal fungi (AMF) enhance the tolerance of Euonymus maackii Rupr. at a moderate level of salinity.

PloS one·2020

Same author

NGF mediates protection of mesenchymal stem cells-conditioned medium against 2,5-hexanedione-induced apoptosis of VSC4.1 cells via Akt/Bad pathway.

Molecular and cellular biochemistry·2020

Same author

The role of TRPV1 channels in atherosclerosis.

Channels (Austin, Tex.)·2020

Valproic acid (VPA) significantly enhanced sciatic nerve regeneration and motor function recovery in rats. This study suggests VPA

Area of Science:

Neuroscience
Regenerative Medicine
Pharmacology

Background:

Valproic acid (VPA) is an established antiepileptic and mood-stabilizing drug.
Emerging evidence suggests VPA promotes neurite outgrowth and influences key molecular pathways (ERK, bcl-2, GAP-43) in the spinal cord.

Purpose of the Study:

To investigate the efficacy of VPA in promoting peripheral nerve regeneration and motor function recovery in a rat sciatic nerve injury model.

Main Methods:

A rat sciatic nerve defect was created and bridged using a silicone tube.
Valproic acid (VPA) or saline was locally administered into the tube post-surgery.
Sciatic nerve function index (SFI), electrophysiology, and nerve histology were assessed over 12 weeks.

Main Results:

More Related Videos

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

Preparation of Rat Sciatic Nerve for Ex Vivo Neurophysiology

Preparation of Rat Sciatic Nerve for Ex Vivo Neurophysiology

Published on: July 12, 2022

Related Experiment Videos

Last Updated: Jul 5, 2026

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Published on: November 3, 2017

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

Preparation of Rat Sciatic Nerve for Ex Vivo Neurophysiology

Preparation of Rat Sciatic Nerve for Ex Vivo Neurophysiology

Published on: July 12, 2022

VPA treatment group showed significant improvements in SFI compared to controls.
Electrophysiological studies revealed enhanced motor nerve conduction velocity and action potential amplitude in the VPA group.
Histomorphometrical analysis demonstrated a greater number of regenerated axons and increased myelin sheath thickness in VPA-treated nerves.

Conclusions:

Local administration of VPA effectively enhances sciatic nerve regeneration and functional recovery in rats.
These findings support the potential clinical application of VPA for treating peripheral nerve injuries.