[Transplantation tolerance: European Union meets the challenge]

Recent developments in basic and translational immunology open new exciting perspectives for the induction of transplantation tolerance in the clinic. However, a number of hurdles still need to be overcome before immunosuppressive drugs can be safely withdrawn in solid organ transplant recipients. With this background, the European Commission recently launched several initiatives to tackle unmet needs in transplantation medicine. Herein, we focus attention on the RISET project, an ongoing collaborative effort across the European Union aiming at minimization of immunosuppression on the basis of validated biomarkers.