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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...

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Related Experiment Video

Updated: Jul 5, 2026

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
08:57

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Notch signaling in cardiac development.

Kyle Niessen1, Aly Karsan

  • 1Department of Medical Biophysics, British Columbia Cancer Research Centre, 675 W 10th Ave, Vancouver, BC, Canada V5Z 1L3. akarsan@bccrc.ca.

Circulation Research
|May 24, 2008
PubMed
Summary
This summary is machine-generated.

The Notch signaling pathway is crucial for mammalian heart development, regulating key processes like valve formation and myocardial boundaries. Mutations in this pathway are linked to congenital heart defects in humans.

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Published on: August 10, 2018

Area of Science:

  • Developmental Biology
  • Cardiovascular Research
  • Genetics

Background:

  • The Notch signaling pathway is essential for mammalian cardiac development.
  • Mutations in Notch signaling are linked to human congenital heart defects, including Alagille syndrome and ventricular septal defects.

Purpose of the Study:

  • To review recent findings on Notch pathway mechanisms in cardiac development.
  • To elucidate the role of Notch signaling in ventricular, atrioventricular canal, and outflow tract development.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of gene-targeted mouse studies.
  • Examination of human genetic data related to congenital heart defects.

Main Results:

  • Notch activation in the endocardium regulates ventricular myocardial development.
  • Notch downstream targets Hey1 and Hey2 are vital for atrioventricular canal boundary formation.
  • The Notch pathway influences endothelial-to-mesenchymal transition in heart valve development and cardiac neural crest cell development.

Conclusions:

  • The Notch pathway plays a multifaceted role in cardiac development, impacting various structures and processes.
  • Understanding Notch signaling mechanisms offers insights into congenital heart disease etiology and potential therapeutic targets.